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Management Team PKPD Inc.

Martin Graham
Professor Martin Graham PhD is the Founder of PKPD Incorporated and serves as the Chairman of the Board of Directors. Prof Graham is a graduate of Leeds University, UK (Pharmacology and Microbiology BSc, Joint Honors) and obtained his PhD from the University of London (Institute and Cancer Research, Royal Marsden Hospital, London UK). He conducted post-doctoral research in anti-cancer drug development at the Beatson Institute (University of Glasgow) before joining Sterling-Winthrop Pharmaceuticals (now Sanofi-Aventis) in both the UK and the US. He has held positions of increasing responsibility during his career and was Director of Pharmacokinetics at Centocor Corporation (Johnson and Johnson), and VP of Research and Development at Gemin X Biotechnologies before founding PKPD Incorporated in 2004. He was President and CEO of PKPD until June 2006 and now serves on the board directors as company Chairman. Dr Graham has extensive R&D experience with both small molecules and protein therapeutics from IND to NDA/BLA and has been involved in numerous regulatory filings in both the US, Japan and Europe for a wide variety of products including Oxaliplatin, Rasburicase, Mitoguazone, Tirapazamine, Alfuzosin and Remicade. Prof Graham is an Honorary Professor of Pharmacokinetics and Pharmacodynamics at the University of Bradford, Yorkshire, UK and is specialist in PK/PD modeling clinical trial simulation. He is the author of a text book on the “Pharmacokinetics of Cancer Chemotherapy” and has a substantial publication record in the area of pharmacokinetics, drug metabolism and clinical pharmacology.

Lynda Graham, MBA
President & CFO

lgraham@pkpdinc.com

 

 

 

Jyoti Sharma, PhD
Associate Director, Pharmacokinetics

 

 

 

 

Laurence H Patterson
Professor Laurence H Patterson is a member of the Board of Directors and consults in medicinal chemistry, drug metabolism and pharmacokinetics for PKPD Incorporated. Prof Patterson is a graduate of University of Hertfordshire, UK (BSC (hons) Applied Biology) and obtained his PhD from the University of London (Chelsea Dept of Pharmacy). He spent several years in the pharmaceutical industry as a senior scientist in R & D with Fisons Pharma (now Astra Zeneca). Subsequently he held several academic positions at DeMontfort University progressing to Professor of Pharmaceutical biochemistry and then on to Professor of medicinal chemistry and Head of the Department of Pharmaceutical and Biological Chemistry at The School of Pharmacy, University of London. He is currently Director of the Institute of Cancer Therapeutics (ICT), University of Bradford and is a Fellow of the Royal Society of Chemistry. He has published over 100 papers and patents concerned with the discovery and development of new drugs with particular interest in the oncology field. He consults widely with pharmaceutical and biotechnology in the areas of drug discovery, medicinal chemistry, drug metabolism and pharmacokinetics. Prof Patterson is responsible for the discovery of AQ4N, a tumour hypoxia activated agent in Phase 1/II Trials. He is also a founding director of Biostatus Ltd with substantial interest in the development of live cell probes. (lpatterson@pkpdinc.com)

Paul Loadman
Dr Paul Loadman is responsible for Pharmacokinetic data analyses at PKPD Incorporated and is a consultant in drug metabolism and bioanalysis. Dr Loadman has a honours degree in Applied Biology (Pharmacology and Immunology) and obtained his PhD from the University of Bradford, UK, studying the pharmacokinetics and metabolism of anti-cancer drugs. Dr Loadman is an expert in the bioanalysis of drugs and has studied a wide range of clinically available and novel small molecules including antimetabolites, platinating and alkylating agents, peptides and antivascular compounds. Dr Loadman is actively involved in the design, analysis and reporting of pre-clinical and clinical pharmacokinetic studies and acts as a pharmacokinetic and drug metabolism consultant for numerous US and European pharmaceutical and biotechnology companies. (ploadman@pkpdinc.com)

Kevin Adams
Dr Kevin Adams is responsible for business development activities at PKPD Incorporated. Dr Adams is a graduate of the University of Leeds (BSc (Hons) in Genetics) and was awarded a D.Phil. by the University of York. After a period of post-doctoral research in Genetic Toxicology at Swansea University and the Zentrum fur Tumorforschung at the University of Essen (Germany), he moved into industry at Huntingdon Life Sciences (HLS). In 14 years at HLS he held a variety of positions including Head of Cellular and Genetic Toxicology before moving into a more commercial role as Bioscience business development manager. After leaving HLS, he spent two years in a European sales and marketing role with BD Biosciences before moving to the University of Bradford to manage their Bio-Incubation programme. In his various roles Dr Adams has developed a range of skills and experience covering laboratory and project management, Good Laboratory Practice, regulatory toxicology and business development. Dr Adams is also closely involved with a number of new businesses through Bradford University’s Bio-Incubation programme. This has included supporting business incorporation, business planning, fund raising, grant writing, business development and PR. (kadams@pkpdinc.com)

Stuart Nelson
Mr Stuart Nelson, BSc (Hons) is responsible for Project Management and Business Development at PKPD. Stuart is a graduate scientist with a BSc Honours degree in Biotechnology, obtained at the University of Strathclyde in Glasgow, Scotland. After graduation he worked at the University of Sheffield, UK studying the role of Epstein Barr Virus in skin lymphoma. From here he moved to the Centre for Ecology and Hydrology in Huntingdon, UK. With a strong background in molecular biology Stuart moved into industry in 1995 with a commercial supplier in the biomedical research field. As Director of Scientific Services his role was to develop the scientific division of the Company and set-up molecular biology, embryology and transgenic technology laboratories. He was also responsible for business development, project management and contract negotiation. More recently, Stuart has been involved in a similar role as Commercial Manager for the Institute of Cancer Therapeutics at the University of Bradford, UK. As well as business development, his role involves the management of projects for the evaluation of novel therapeutic compounds, including preclinical evaluation as well as pharmacokinetic and pharmacodynamic analysis. (snelson@pkpdinc.com)

Dr Gerald Fetterly Jr., PhD
Dr Fetterly is consultant pharmcokineticist for PKPD and Director of the PK/PD Core Facility at the Rosswell Park Cancer Institute. Prior to joining Roswell Park Cancer Institute, Dr. Fetterly worked at Cognigen where he performed population PK/PD modeling among other projects, and provided consulting services for both industry and academia to assess the impact of patient factors that are sources of variability in not only pharmacokinetics but also the PK/PD relationships for both efficacy and safety, mainly for oncology and neuropharmacology drugs. At Cognigen, he led and managed interdepartmental projects in Clinical Pharmacology, provided sparse sampling designs for clinical pharmacology trials, provided clinical pharmacology services for regulatory strategy during Advisory Board and Sponsor/FDA meetings, reviewed the non-clinical as well as clinical pharmacology development sections of various INDs and NDAs, as well as assisted in the interpretation of preclinical data and extrapolation of implications for human clinical development utilizing PK/PD modeling approaches.

From 2000-2002, Dr. Fetterly was a clinical pharmacology and biopharmaceutics reviewer at the FDA. The experience of working with the agency has allowed him to supply insight, about the necessary components for a successful IND and NDA submission, along with guiding dose selection during the drug development process.

Dr. Fetterly received his doctoral degree in Pharmaceutics from the University at Buffalo in 2000. He possesses considerable expertise in developing oncology agents and the liposomal encapsulation of drugs. Specifically, his doctoral work and subsequent publications focused on an extensive comparison of the PK/PD relationships of various anticancer drugs, such as liposomal paclitaxel, trabectedin, and mTOR inhibitors.

Srinivas Chunduru
Srinivas has over 17 years experience in the pharmaceutical industry, focused in oncology and anti-infectives. He has discovered and advanced 4 compounds into Phase I/II clinical trials. Prior to joining PKPD, he co-founded Elixeon Pharmaceuticals with Martin Graham to develop radiation sensitizers. He also worked at TetraLogic Pharmaceuticals and ViroPharma. He holds a Ph.D. in Biochemistry and received post- doctoral training at the University of Pennsylvania and at St. Jude Children’s Research Hospital. His areas of expertise include assay development, hit to lead optimization, high throughput screening, preclinical-to-IND, and bio-marker development.